Structure-function of cytochromes P450 and flavin-containing monooxygenases: implications for drug metabolism.
نویسندگان
چکیده
This article is a report on a symposium held at Experimental Biology '98 in San Francisco, California. Recent developments in site-directed mutagenesis, computer-modeling, and mechanistic analysis of cytochromes P450 and flavin-containing monooxygenases are described. A unifying theme is the elaboration of general approaches for understanding and predicting the function of individual forms of these enzymes. A related goal is the production of soluble forms of mammalian cytochromes P450 for X-ray crystallography.
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ورودعنوان ژورنال:
- Drug metabolism and disposition: the biological fate of chemicals
دوره 26 12 شماره
صفحات -
تاریخ انتشار 1998